Preclinical Imaging

IVIS Lumina XRMS
Please contact Dr Agatha Labrinidis for further information.
Located at Frome Road.
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Information on the IVIS Lumina XRMS
The IVIS Lumina XRMS Live Animal Biophotonic Imaging System is a real-time in vivo imaging system that offers users the flexibility to image fluorescent and bioluminescent reporters to visualise, monitor and record specific genetic and cellular activity within a living organism.
Bioluminescence Imaging is a high throughput, high-sensitivity, low-noise and non-invasive technique which captures, quantifies and analyses the light emitted by a living organism as the result of a chemical reaction where chemical energy is converted to light energy. This technique can be used to track gene expression and monitor the spread of a disease. It can be applied to drug development.
- a feature story in the ÐÂÀË²ÊÆ±an.

Micro-CT Bruker 1276 Scanner
Please contact Dr Agatha Labrinidis for further information.
Located at ÐÂÀË²ÊÆ± Health & Medical Sciences Building.
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Information on the Micro-CT Bruker 1276 Scanner
The 1276 is a high performance, stand-alone, fast, desk-top in vivo micro-CT with continuously variable magnification for scanning small laboratory animals such as mice and rats and also biological samples. It has an unrivaled combination of high resolution, big image size, possibility for round and spiral (helical) scanning and reconstruction, and low dose imaging. The image field of view (up to 80 mm wide and more than 300 mm long) allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants. Further, the 1276 in vivo micro-CT administers low radiation dose to the animals allowing multiple scans in longitudinal pre-clinical studies without the risk of unwanted radiation-induced side effects. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with fastest scanning cycle 3.9 sec.
The 1276 allows reconstructing non-invasively any cross section(s) through the animal body with possibilities to convert reconstructed datasets into realistic 3D-image and calculate internal morphological parameters including specific bone structural parameters.